Metered Dose Inhaler (MDI) Technology

A comprehensive overview of MDIs including development, manufacture, regulation and market potential

20-21 Feb 2019

& 18-19 Sep 2019

GBP 1,499 1,299 *
EUR 2,099 1,819 *
USD 2,338 2,026 *
* When you book before 21 Dec

Book now

Course overview

This interactive seminar will provide a comprehensive overview of metered-dose inhaler technology. It will clarify the therapeutic targets and look at delivery technologies. Participants will gain a valuable insight into market potential and receive detailed information on the manufacturing process, quality and inspection requirements and the regulatory pathways to follow.

This seminar will be beneficial for those new to the area and those who require a refresher on the opportunities with this technology. The seminar format will include practical workshops and there will be plenty of opportunity for discussion with the trainer who has significant experience in this field.

Media Partner

Inhalationlogo

Who should attend?

  • Respiratory pharma professionals who need to understand MDI technology and its opportunities
  • Medical device professionals new to working in the area of MDIs or those who need a refresher
  • Medical device business development managers
  • Respiratory professionals in R & D
  • Medical device manufacturers working in the respiratory market

Programme day one

Therapeutic targets

  • Very brief history
  • Asthma
  • COPD
  • Other local
    • CF
  • Systemic
    • Why?
    • Why not?
  • Key characteristics
    • Particle size
    • Why?

Markets

  • Disease distribution
    • Historic
    • Current
    • Future
    • Drivers
  • Manufacture vs use
    • International procurement – Double and triple counting
  • Regulation
    • Geographic differences
  • Pricing
    • vs cost
    • vs market – vs product

Delivery technologies

  • Inhalation
    • MDI
    • DPI: unit dose, multi-dose, reservoir
    • Nebuliser: energy source, SMI, other
  • Other
    • Oral
    • Injectable – Nasal
  • Cost considerations – Design
    • Scale
    • Investment
    • Cost of goods
  • Typical breakdown
    • Sensitivities

Workshop

  • Ranking of competitive technologies for different opportunities

Programme day two

The MDI – overview

  • Hardware
    • Valves
    • Canister
    • Actuators
    • Sources
  • Formulations
    • Solution
    • Suspensions
    • Other

The MDI – manufacturing process

  • Process
    • Single-stage
    • Multi-stage
    • Cold
    • Flow
    • Areas

The MDI – manufacturing equipment

  • Scale
    • Lab
    • Small
    • Medium
    • Large

The MDI – quality and inspection

  • Incoming
  • Release

The MDI – other performance

  • Prime and re-prime
  • Thermal

Challenges and opportunities for the MDI – development and technical

  • Performance
  • Stability
  • Compatibility
  • Hardware availability
  • Manufacturing processes/equipment

Challenges and opportunities for the MDI and DPI

  • Co-ordination
    • Breath actuation
    • Training
    • Breath co-ordination
  • Deposition
    • Spacers
    • Holding chambers
  • Enhancements
  • Changing therapeutic approaches
    • Once daily
    • Combinations

Workshop (including coffee break)

  • SWOT MDI vs multi-dose DPI
  • SWOT MDI vs Soft Mist Inhaler

Regulation of inhalation products

  • Regulatory landscape (EU, US, RoW)
    • Generic
    • New combination
    • New chemical entity
    • Time to market
    • Success rate
    • Key expectations
  • Changing environment
    • Combination product approaches
    • Human factors
    • Bioequivalence

Presenter

David Howlett

In 2003 David established PharmaDelivery Solutions Ltd as a specialised consultancy service in the field of drug delivery combination products (especially respiratory) device technology. This has led to involvement in projects with focus in pulmonary, nasal and other delivery routes, with an international client base. Much of the activity of PharmaDelivery Solutions Ltd is focused in the area of development programme support, regulatory GAP analysis and generation of documentation supporting development and test programmes, together with data review and contingency evaluation.

David has over 35 years experience in the development, industrialization and approval of inhalation drug delivery systems, combination products and medical devices.

PharmaDelivery Solutions Ltd has provided input ranging from GAP analysis and comment to complete remedial implementation in areas including

• Design Control
• Risk Management
• Materials strategies
• Regulatory documentation
• Technical reviews and opinion

In addition to activities supporting commercial organizations, David has been involved in the following roles;

Honorary Teaching Fellow in the School of Pharmacy and Pharmaceutical Sciences at the University of Manchester and is author/ tutor for the Pharmaceutical Industry Advanced Training (PIAT) MSc module on Inhalation dosage forms.

A UK national expert representing the British Standards Institute on ISO TC84 developing new international standards for pulmonary and nasal delivery devices syringes and catheters.

David has also worked with the United Nations and various national governments to develop and establish transition strategies from the use of CFC in Metered Dose Inhalers and to secure appropriate budgets from the Multi-lateral fun for the implementation of the Montreal Protocol in emerging markets around the world.

Book now

20-21 Feb 2019
20-21 Feb 2019 Rembrandt Hotel, London GBP 1,499.00
EUR 2,099.00
USD 2,338.00
+ VAT @ 20.00%
GBP 1,299.00
EUR 1,819.00
USD 2,026.00
Until 21 Dec
Enrol now
18-19 Sep 2019
18-19 Sep 2019 Venue not yet confirmed GBP 1,499.00
EUR 2,099.00
USD 2,338.00
+ VAT @ 20.00%
Enrol now